REQ-10051508
6月 20, 2025
Switzerland

摘要

Novartis Biomedical Research (BR) serves as the innovation engine of Novartis, driving cutting-edge approaches to deliver therapeutic breakthroughs for patients. Within BR, the Discovery Sciences department pioneers early-stage drug discovery and promotes innovative therapeutics to tackle challenging disease targets.
The Protein Sciences group in Discovery Sciences is an interdisciplinary team specializing in protein biochemistry, biophysics, NMR, X-ray crystallography, and electron microscopy. Our focus is to enable target-based hit identification, validation, and structure-guided drug discovery, with an emphasis on challenging targets such as membrane proteins.
We are seeking a highly skilled and motivated Research Scientist / Senior Scientist with a strong background in protein expression and purification, ideally including experience with membrane proteins, to join our team in Basel, Switzerland. This is a unique opportunity to contribute to drug discovery across multiple disease areas within a dynamic, collaborative environment that values curiosity, innovation, and teamwork.

About the Role

Responsibilities

You will work to produce high-quality proteins for drug discovery, focusing on small molecule hit generation, validation, and structural biology. Key responsibilities include:

  • Express proteins insect and mammalian cell culture systems.
  • Purify proteins using chromatography techniques and FPLC equipment to enable downstream assays and structural biology for drug discovery.
  • Collaborate with team members to enable cryo-EM structural characterization of membrane proteins.
  • Optimize protocols and processes through literature research, ideation and hands-on wet lab exploration.
  • Work closely in a matrix setting with lab associates and present findings to project teams.
     

Minimum Requirements

  • Completed apprenticeship as a laboratory technician with 2 years of practical work experience or Bachelor/Masters in biochemistry, biology, molecular biology, life sciences, or a related field with strong experience in wet lab work.
  • In-depth theoretical knowledge and hands-on experience in protein biochemistry, including expression, purification, and characterization.
  • Strong collaboration, organizational, and communication skills in oral and written English, with the ability to effectively present results in team settings.
  • Proactive interest in acquiring new techniques in protein biochemistry, biophysics, and structural biology.
     

Desirable Requirements

  • Hands-on experience in membrane protein expression, purification, characterization, and familiarity with cryo-EM workflows (sample preparation, grid handling).
  • Prior exposure to an industrial research environment.
  • Familiarity with software tools for structural analysis and AI driven protein construct design (PyMol, AlphaFold, etc.).

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? http://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: http://talentnetwork.novartis.com/network

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: http://www.novartis.com/careers/benefits-rewards

Biomedical Research
Pharma Research
Switzerland
Basel (City)
Research & Development
Full time
Regular
No

Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.

A female Novartis scientist wearing a white lab coat and glasses, smiles in front of laboratory equipment.
REQ-10051508

Research Scientist / Senior Scientist – Protein Sciences (Novartis Biomedical Research)

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